Milano began her career at age eight after winning a role in an open audition for a national tour of Annie. She was one of the four picked out of an audition with over 1500 girls. She appeared in television commercials and off-Broadway productionsAt age 10, she won her first major role in the television show, Who's the Boss?, alongside Tony Danza, Judith Light, Danny Pintauro, and Katherine Helmond. She starred as Samantha Micelli, the daughter of Danza's character. After Milano won the role, she and her father relocated from Staten Island to Hollywood. The rest of the family followed a year later, because her mother was initially unwilling to give up her home life "for a show that wasn't a guarantee." Although born and raised in Brooklyn, Milano had trouble getting this accent, because she worked to lose it to land more roles in the theater, including in a stage adaption of Jane Eyre''
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